Incurable centers on a support group for people with supernatural problems.

Type: Scripted

Languages: English

Status: In Development

Runtime: None minutes

Premier: None

Incurable - Suicide - Netflix

Suicide is the act of intentionally causing one's own death. Risk factors include mental disorders such as depression, bipolar disorder, schizophrenia, personality disorders, and substance abuse — including alcoholism and the use of benzodiazepines. Other suicides are impulsive acts due to stress such as from financial difficulties, troubles with relationships, or bullying. Those who have previously attempted suicide are at a higher risk for future attempts. Suicide prevention efforts include limiting access to methods of suicide — such as firearms, drugs, and poisons; treating mental disorders and substance misuse; proper media reporting of suicide; and improving economic conditions. Even though crisis hotlines are common, there is little evidence for their effectiveness. The most commonly used method of suicide varies between countries, and is partly related to the availability of effective means. Common methods of suicide include hanging, pesticide poisoning, and firearms. Suicides resulted in 828,000 global deaths in 2015, an increase from 712,000 deaths in 1990. This makes suicide the 10th leading cause of death worldwide. Approximately 0.5-1.4% of people die by suicide, roughly 12 per 100,000 individuals per year. Three quarters of suicides globally occur in the developing world. Rates of completed suicides are generally higher in men than in women, ranging from 1.5 times as much in the developing world to 3.5 times in the developed world. Suicide is generally most common among those over the age of 70; however, in certain countries, those aged between 15 and 30 are at the highest risk. Europe had the highest rates of suicide by region in 2015. There are an estimated 10 to 20 million non-fatal attempted suicides every year. Non-fatal suicide attempts may lead to injury and long-term disabilities. In the Western world, attempts are more common in young people and in females. Views on suicide have been influenced by broad existential themes such as religion, honor, and the meaning of life. The Abrahamic religions traditionally consider suicide as an offense towards God, due to the belief in the sanctity of life. During the samurai era in Japan, a form of suicide known as seppuku (harakiri) was respected as a means of making up for failure or as a form of protest. Sati, a practice outlawed by the British Raj, expected the Indian widow to kill herself on her husband's funeral fire, either willingly or under pressure from her family and society. Suicide and attempted suicide, while previously illegal, are no longer so in most Western countries. It remains a criminal offense in many countries. In the 20th and 21st centuries, suicide has been used on rare occasions as a form of protest, and kamikaze and suicide bombings have been used as a military or terrorist tactic.

Incurable - Pathophysiology - Netflix

There is no known unifying underlying pathophysiology for either suicide or depression. It is however believed to result from an interplay of behavioral, socio-environmental and psychiatric factors. Low levels of brain-derived neurotrophic factor (BDNF) are both directly associated with suicide and indirectly associated through its role in major depression, posttraumatic stress disorder, schizophrenia and obsessive–compulsive disorder. Post-mortem studies have found reduced levels of BDNF in the hippocampus and prefrontal cortex, in those with and without psychiatric conditions. Serotonin, a brain neurotransmitter, is believed to be low in those who die by suicide. This is partly based on evidence of increased levels of 5-HT2A receptors found after death. Other evidence includes reduced levels of a breakdown product of serotonin, 5-Hydroxyindoleacetic acid, in the cerebral spinal fluid. Direct evidence is however hard to gather. Epigenetics, the study of changes in genetic expression in response to environmental factors which do not alter the underlying DNA, is also believed to play a role in determining suicide risk.

Incurable - References - Netflix